DrugMetZ DB
A Database on human drug metabolizing cytochromes
Accession No043DE
CategoryAnalgesics
Functional SpecificityNot Available
Drug NamePhenacetin
   
IUPAC NameN-(4-ethoxyphenyl)ethanamide
Chemical FormulaC10H13NO2
Smiles StringCCOC1=CC=C(C=C1)NC(=O)C
Drug DescriptionUsed to treat rheumatoid arthritis (subacute type);Intercostal neuralgia;Some forms of ataxia
Metabolizing EnzymeCYP1A2
EC NumberEC 1.14.14.1
Tissue SpecificityLiver,Extra hepatic organ
Cellular LocationEndoplasmic reticulam,Membrane bound
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen.
Protein Sequence > sp|P05177|CP1A2_HUMAN Cytochrome P450 1A2 (EC 1.14.14.1) ALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIR QALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPY NQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDI TGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFR HSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLF LAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARRFSIN
GeneCYP1A2
Gene IDNM_000761
Metabolic PhasePhase1
MetabolismHepatic
OrganismHomo sapiens
ReferenceFunctional characterization of four allelic variants of human cytochrome P450 1A2.Zhou H, Josephy PD, Kim D, Guengerich FP.Arch Biochem Biophys. 2004 Feb 1;422(1):23-30.